Microfluidics for biosensing with additive manufacturing

Capillary-driven microfluidic systems have garnered considerable attention lately for their promising applications in point-of-care testing. Nevertheless, there remain various challenges to overcome in order to develop dependable and practical point-of-care detection devices. In this project, we delve into addressing the issues stemming from diffusion and mixing within such devices utilized for biosensing. Taking advantage of current state-of-art manufacturing capabilities we have proposed capillary valves, micromixers and other fluidic element along with the associated microfluidic arrays to tackle these challenges. The outcomes of our comprehensive numerical simulations and experimental investigations are groundbreaking, demonstrating the efficacy of our innovative design for biosensing applications—a contribution previously unreported in the literature.

Funding:

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 813863. Based on the AL4683-ATL-C__1.4.7_Agreement between LEITAT as the participant in BORGES and UPC.

Publications

Pooya Azizian, Jasmina Casals-Terré, Jordi Ricart, Joan M. Cabot (2023) Capillary-Driven Microfluidics: Impacts of 3D Manufacturing on Bioanalytical Devices. P; Analyst, 148, 2657- 2675  https://doi.org/10.1039/D3AN00115F

Pooya Azizian, Jasmina Casals-Terré, Jordi Ricart, Joan M. Cabot;  (2023) Diffusion-Free Valve for Preprogrammed Immunoassay with Capillary Microfluidics. Microsyst Nanoeng, 9, 91. https://doi.org/10.1038/s41378-023-00568-2

Pooya Azizian, Jasmina Casals-Terré, Elena Guerrero-SanVicente, Ruta Grinyte, Jordi Ricart and Joan M. Cabot (2023) Coupling Capillary-Driven Microfluidics with Lateral Flow Immunoassay for Signal Enhancement. t; Biosensors, 13, 832. https://doi.org/10.3390/bios13080832