Microfluidics for Sweat Continous Monitoring

Microfluidics has allowed testing devices to move from the lab to the bed side of the patient. In this project, the technology is moving one step further in order to continuously monitor  in minute droplets of sweat thanks to microfluidics. A novel microfluidic circuit is proposed to collect sweat in a timed manner and allocate it on the reading point of the sensors. In this way, a more controlled environment of analysis can be provided to the sensors avoiding contamination from skin and  providing more robust measurements. The solution offers an efficient passive sweat collection system, which minimizes dead volumes and the manipulation. The microfluidics isolate the different samples and ensure a good accuracy and repeatability of the sensor.

Nowadays, most biomarkers are monitored on blood. However some studies has started to work on sweat. This project will cross correlate measure from different biomarkers and develop a novel microfluidic circuit with the corresponding electronics to continously montior them.

The project results will be commercialized by ONALABS.



G. Rabost-Garcia, V. Colmena, J.Aguilar-Torán, J.Vieyra Galí, J. Punter-Villagrasa, J.Casals-Terré et al. (2023) Non-Invasive Multiparametric Approach To Determine Sweat–Blood Lactate Bioequivalence. ACS Sensors DOI: 10.1021/acssensors.2c02614

Aguilar-Torán, J.; Rabost-Garcia, G.; Toinga-Villafuerte, S.; Álvarez-Carulla, A.; Colmena-Rubil, V.; Fajardo-Garcia, A.; Cardona-Bonet, A.; Casals-Terré, J.; Muñoz-Pascual, X.; Miribel-Català, P.; et al. Novel Sweat-Based Wearable Device for Advanced Monitoring of Athletic Physiological Biometrics. Sensors 202323, 9473. https://doi.org/10.3390/s23239473

G. Rabost-Farcia, F.J.Munoz-Pascual, J. Casals- Terre, J. Farré-Lladós Microfluidic system and method for continuous monitoring of metabolites and/or properties of biofluids US Patent App. 18/009,043

Rabost-Garcia, G.; Farré-Lladós, J.; Casals-Terré, J. Recent Impact of Microfluidics on Skin Models for Perspiration Simulation. Membranes 202111, 150. https://doi.org/10.3390/membranes11020150